About
ALS/Parkinsonism-Dementia Complex of the Kii peninsula, Japan (Kii ALS/PDC)
The southern area in the Kii peninsula of Japan (Muro district) is one of the hyperendemic foci of amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia complex (PDC), together with Guam island. High accumulation of phosphorylated tau protein in neurons and glial cells in the central nervous system is the hallmark of ALS/PDC. Epidemiologically, marked decline in ALS incidence and concomitant increase in PDC incidence occurred in 1970s, suggesting changes of some unsolved environmental factors may have induced phenotypic changes of the disease. A research on genetic factors, environmental factors and their interaction is now going on.
Shigeki Kuzuhara, MD,PhD. Professor Emeritus of Neurology, Mie University
Topics
Archive- Publication in the Journal "Acta Neuropathologica" (15 May 2024)
The titled "Aberrant CHCHD2-associated mitochondriopathy in Kii ALS/PDC astrocytes" by Leventoux N, Morimoto S et al. was published in the Jounal "Acta Neuropathologica (Impact Factor: 16.2)"
- Publication in the Journal "Proc Natl Acad Sci U S A" (19 December 2023)
The titled "Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold" by Ci C et al. was published in the Jounal "Proc Natl Acad Sci U S A (Impact Factor: 12.0)"
- Publication in the Journal "Neurological Sciences" (24 October 2023)
The titled "Protein profiling of extracellular vesicles from iPSC-derived astrocytes of patients with ALS/PDC in Kii peninsula" by Kobayashi H et al. was published in the Jounal "Neurological Sciences (Impact Factor: 3.2)"
Schedule
Archive- Public Lecture in Minami-Ise Town
Minami-Ise Town Hall
October 13, 2013
- Neuropathological Workshop
Tokyo Metropolitan Institute of Gerontology
August 25, 2013
- Guam Research Project
Visiting to Guam at August 16-18, 2013