Research Project
Ⅰ Epidemiology, Environmental factors
Aim: To reveal recent epidemiological changes and environmental factors those have been influencing epidemiological changes.
Ⅱ Gene
Aim: To reveal genetic background with sophisticated technology, such as linkage analysis, candidate gene analysis, mitochondrial gene analysis and next generation sequence.
Ⅲ Proteinopthy and Neuroathology
Aim: To reveal characteristic changes regarding multiple proteinopathy, such as tau protein,α-synuclein and TDP-43.
Ⅳ Neuroradiology
Aim: To reveal neuroradiological features using MRI, SPECT and PET.
Ⅴ Pathomechanism
Aim: To reveal pathomechanism including oxidative stress, nitrative stress, citrulline expression and glial pathology.
Ⅵ iPS cell
Aim: To develop candidate chemicals those have a modifiable effect on disease progression.
Ⅶ Clinical Trial
Aim: To do clinical trial using promising medicine.
Ⅷ Guam Research
Aim: To compare epidemiology, clinical findings, environmental factors and genetic background between two endemic foci.
Ⅸ Papua Research
Aim: Joint research with The Research Institute for Humanity and Nature.