About
ALS/Parkinsonism-Dementia Complex of the Kii peninsula, Japan (Kii ALS/PDC)
The southern area in the Kii peninsula of Japan (Muro district) is one of the hyperendemic foci of amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia complex (PDC), together with Guam island. High accumulation of phosphorylated tau protein in neurons and glial cells in the central nervous system is the hallmark of ALS/PDC. Epidemiologically, marked decline in ALS incidence and concomitant increase in PDC incidence occurred in 1970s, suggesting changes of some unsolved environmental factors may have induced phenotypic changes of the disease. A research on genetic factors, environmental factors and their interaction is now going on.
Shigeki Kuzuhara, MD,PhD. Professor Emeritus of Neurology, Mie University
Topics
Archive- Publication in the Journal "Brain Pathology"
The titled "Optineurin pathology in the spinal cord of amyotrophic lateral sclerosis/parkinsonism-dementia complex patients in Kii Peninsula, Japan." by S.Morimoto et al. was published in the Jounal "Brain Pathology".
- Publication in the Journal "Neuropathology"
The titled "Amyotrophic lateral sclerosis and parkinsonism-dementia complex of the Hohara focus of the Kii Peninsula: A multiple proteinopathy?" by M.Mimuro et al. was published in the Jounal "Neuropathology".
- Publication in the Journal "Frontiers in Neuroscience"
The titled "Nitrative Stress and Tau Accumulation in Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex (ALS/PDC) in the Kii Peninsula, Japan." by Y.Hata et al. was published in the Jounal "Frontiers in Neuroscience".
Schedule
Archive- Public Lecture in Minami-Ise Town
Minami-Ise Town Hall
October 13, 2013
- Neuropathological Workshop
Tokyo Metropolitan Institute of Gerontology
August 25, 2013
- Guam Research Project
Visiting to Guam at August 16-18, 2013