Yasumasa Kokubo MD, PhD
Mie University,
Graduate School of Regional Innovation Studies
Kii ALS/PDC Research Center
1577 Kurimamachiyacho, Tsu, Mie
514-8507, Japan
Phone & Fax:+81-059-231-5117


ALS/Parkinsonism-Dementia Complex of the Kii peninsula, Japan (Kii ALS/PDC)

The southern area in the Kii peninsula of Japan (Muro district) is one of the hyperendemic foci of amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia complex (PDC), together with Guam island. High accumulation of phosphorylated tau protein in neurons and glial cells in the central nervous system is the hallmark of ALS/PDC. Epidemiologically, marked decline in ALS incidence and concomitant increase in PDC incidence occurred in 1970s, suggesting changes of some unsolved environmental factors may have induced phenotypic changes of the disease. A research on genetic factors, environmental factors and their interaction is now going on.

Shigeki Kuzuhara, MD,PhD. Professor Emeritus of Neurology, Mie University


Publication in the Journal "Proc Natl Acad Sci U S A" (19 December 2023)

The titled "Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold" by Ci C et al. was published in the Jounal "Proc Natl Acad Sci U S A (Impact Factor: 12.0)"

Publication in the Journal "Neurological Sciences" (24 October 2023)

The titled "Protein profiling of extracellular vesicles from iPSC-derived astrocytes of patients with ALS/PDC in Kii peninsula" by Kobayashi H et al. was published in the Jounal "Neurological Sciences (Impact Factor: 3.2)"

Publication in the Journal "Neurology" (21 September 2022)

The titled "APOE Alleles With Tau and Aβ Pathology In Patients With Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex in the Kii Peninsula" by Sasaki R et al. was published in the Jounal "Neurology (Impact Factor: 9.91)"


Public Lecture in Minami-Ise Town

Minami-Ise Town Hall

October 13, 2013

Neuropathological Workshop

Tokyo Metropolitan Institute of Gerontology

August 25, 2013

Guam Research Project

Visiting to Guam at August 16-18, 2013