Contact
Yasumasa Kokubo MD, PhD
Mie University,
Graduate School of Regional Innovation Studies
Kii ALS/PDC Research Center
1577 Kurimamachiyacho, Tsu, Mie
514-8507, Japan
Phone & Fax:+81-059-231-5117
E-mail:
kii-project@clin.medic.mie-u.ac.jp


About

ALS/Parkinsonism-Dementia Complex of the Kii peninsula, Japan (Kii ALS/PDC)

The southern area in the Kii peninsula of Japan (Muro district) is one of the hyperendemic foci of amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia complex (PDC), together with Guam island. High accumulation of phosphorylated tau protein in neurons and glial cells in the central nervous system is the hallmark of ALS/PDC. Epidemiologically, marked decline in ALS incidence and concomitant increase in PDC incidence occurred in 1970s, suggesting changes of some unsolved environmental factors may have induced phenotypic changes of the disease. A research on genetic factors, environmental factors and their interaction is now going on.

Shigeki Kuzuhara, MD,PhD. Professor Emeritus of Neurology, Mie University

Topics

Archive
Publication in the Journal "Journal of Neuropathology & Experimental Neurology" (11 July 2020)

The titled "e PathomeBrain Transcriptome Analysis Links Deficiencies of Stress-Responsive Proteins to thchanism of Kii ALS/PDExpression of Mutant Ubiquitin and Proteostasis Impairment in Kii Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex Brains" by Bert M Verheijen et al. was published in the Jounal "Journal of Neuropathology & Experimental Neurology (Impact Factor: 3.714)"

Publication in the Journal "Antioxidants" (14 May 2020)

The titled "Brain Transcriptome Analysis Links Deficiencies of Stress-Responsive Proteins to the Pathomechanism of Kii ALS/PDC." by Morimoto S et al. was published in the Jounal "Antioxidants (Impact Factor: 4.520)"

30th International Symposium on ALS/MND (ALS/MND 2019)

30th International Symposium on ALS/MND (ALS/MND 2019)(Dec 4-6, 2019, Perth, Australia)

Yasumasa Kokubo presented the following theme「Poster Session: Abnormal accumulation of citrullinated proteins in ALS/PDC of the Kii peninsula of Japan

Shigeki Kuzuhara presented the following theme「Invited Oral Session: ALS-PDC of the Kii Peninsula,Japan: clinical and neuropathological features and epidemiology

Schedule

Archive
Public Lecture in Minami-Ise Town

Minami-Ise Town Hall

October 13, 2013

Neuropathological Workshop

Tokyo Metropolitan Institute of Gerontology

August 25, 2013

Guam Research Project

Visiting to Guam at August 16-18, 2013