Contact
Yasumasa Kokubo MD, PhD
Mie University,
Graduate School of Regional Innovation Studies
Kii ALS/PDC Research Center
1577 Kurimamachiyacho, Tsu, Mie
514-8507, Japan
Phone & Fax:+81-059-231-5117
E-mail:
kii-project@clin.medic.mie-u.ac.jp


About

ALS/Parkinsonism-Dementia Complex of the Kii peninsula, Japan (Kii ALS/PDC)

The southern area in the Kii peninsula of Japan (Muro district) is one of the hyperendemic foci of amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia complex (PDC), together with Guam island. High accumulation of phosphorylated tau protein in neurons and glial cells in the central nervous system is the hallmark of ALS/PDC. Epidemiologically, marked decline in ALS incidence and concomitant increase in PDC incidence occurred in 1970s, suggesting changes of some unsolved environmental factors may have induced phenotypic changes of the disease. A research on genetic factors, environmental factors and their interaction is now going on.

Shigeki Kuzuhara, MD,PhD. Professor Emeritus of Neurology, Mie University

Topics

Archive
Publication in the Journal "Brain Pathology"

The titled "Optineurin pathology in the spinal cord of amyotrophic lateral sclerosis/parkinsonism-dementia complex patients in Kii Peninsula, Japan." by S.Morimoto et al. was published in the Jounal "Brain Pathology".

Publication in the Journal "Neuropathology"

The titled "Amyotrophic lateral sclerosis and parkinsonism-dementia complex of the Hohara focus of the Kii Peninsula: A multiple proteinopathy?" by M.Mimuro et al. was published in the Jounal "Neuropathology".

Publication in the Journal "Frontiers in Neuroscience"

The titled "Nitrative Stress and Tau Accumulation in Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex (ALS/PDC) in the Kii Peninsula, Japan." by Y.Hata et al. was published in the Jounal "Frontiers in Neuroscience".

Schedule

Archive
Public Lecture in Minami-Ise Town

Minami-Ise Town Hall

October 13, 2013

Neuropathological Workshop

Tokyo Metropolitan Institute of Gerontology

August 25, 2013

Guam Research Project

Visiting to Guam at August 16-18, 2013