Yasumasa Kokubo MD, PhD
Mie University,
Graduate School of Regional Innovation Studies
Kii ALS/PDC Research Center
1577 Kurimamachiyacho, Tsu, Mie
514-8507, Japan
Phone & Fax:+81-059-231-5117


ALS/Parkinsonism-Dementia Complex of the Kii peninsula, Japan (Kii ALS/PDC)

The southern area in the Kii peninsula of Japan (Muro district) is one of the hyperendemic foci of amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia complex (PDC), together with Guam island. High accumulation of phosphorylated tau protein in neurons and glial cells in the central nervous system is the hallmark of ALS/PDC. Epidemiologically, marked decline in ALS incidence and concomitant increase in PDC incidence occurred in 1970s, suggesting changes of some unsolved environmental factors may have induced phenotypic changes of the disease. A research on genetic factors, environmental factors and their interaction is now going on.

Shigeki Kuzuhara, MD,PhD. Professor Emeritus of Neurology, Mie University


Publication in the Journal "Acta Neuropathologica" (15 May 2024)

The titled "Aberrant CHCHD2-associated mitochondriopathy in Kii ALS/PDC astrocytes" by Leventoux N, Morimoto S et al. was published in the Jounal "Acta Neuropathologica (Impact Factor: 16.2)"

Publication in the Journal "Proc Natl Acad Sci U S A" (19 December 2023)

The titled "Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold" by Ci C et al. was published in the Jounal "Proc Natl Acad Sci U S A (Impact Factor: 12.0)"

Publication in the Journal "Neurological Sciences" (24 October 2023)

The titled "Protein profiling of extracellular vesicles from iPSC-derived astrocytes of patients with ALS/PDC in Kii peninsula" by Kobayashi H et al. was published in the Jounal "Neurological Sciences (Impact Factor: 3.2)"


Public Lecture in Minami-Ise Town

Minami-Ise Town Hall

October 13, 2013

Neuropathological Workshop

Tokyo Metropolitan Institute of Gerontology

August 25, 2013

Guam Research Project

Visiting to Guam at August 16-18, 2013