Yasumasa Kokubo MD, PhD
Mie University,
Graduate School of Regional Innovation Studies
Kii ALS/PDC Research Center
1577 Kurimamachiyacho, Tsu, Mie
514-8507, Japan
Phone & Fax:+81-059-231-5117


ALS/Parkinsonism-Dementia Complex of the Kii peninsula, Japan (Kii ALS/PDC)

The southern area in the Kii peninsula of Japan (Muro district) is one of the hyperendemic foci of amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia complex (PDC), together with Guam island. High accumulation of phosphorylated tau protein in neurons and glial cells in the central nervous system is the hallmark of ALS/PDC. Epidemiologically, marked decline in ALS incidence and concomitant increase in PDC incidence occurred in 1970s, suggesting changes of some unsolved environmental factors may have induced phenotypic changes of the disease. A research on genetic factors, environmental factors and their interaction is now going on.

Shigeki Kuzuhara, MD,PhD. Professor Emeritus of Neurology, Mie University


Publication in the Journal "Neurology"

The titled "Tau imaging detects distinctive distribution of tau pathology in ALS/PDC on the Kii Peninsula." by H.Shinotoh et al. was published in the Jounal "Neurology".

AOPMC2019 Plenary session

6th Asian and Oceanian Parkinson’s Disease and Movement Disorders Congress

April 12-14, 2019 • Hangzhou

Dr. Kokubo was invited as a speaker in Plenary session "Specific Movement Disorders in the Asian-Oceanian Region: Historical and Recent Developments".


Publication in the Journal "Brain Pathology"

The titled "Optineurin pathology in the spinal cord of amyotrophic lateral sclerosis/parkinsonism-dementia complex patients in Kii Peninsula, Japan." by S.Morimoto et al. was published in the Jounal "Brain Pathology".


Public Lecture in Minami-Ise Town

Minami-Ise Town Hall

October 13, 2013

Neuropathological Workshop

Tokyo Metropolitan Institute of Gerontology

August 25, 2013

Guam Research Project

Visiting to Guam at August 16-18, 2013