About
ALS/Parkinsonism-Dementia Complex of the Kii peninsula, Japan (Kii ALS/PDC)
The southern area in the Kii peninsula of Japan (Muro district) is one of the hyperendemic foci of amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia complex (PDC), together with Guam island. High accumulation of phosphorylated tau protein in neurons and glial cells in the central nervous system is the hallmark of ALS/PDC. Epidemiologically, marked decline in ALS incidence and concomitant increase in PDC incidence occurred in 1970s, suggesting changes of some unsolved environmental factors may have induced phenotypic changes of the disease. A research on genetic factors, environmental factors and their interaction is now going on.
Shigeki Kuzuhara, MD,PhD. Professor Emeritus of Neurology, Mie University
Topics
Archive- Publication in the Journal "Neurology" (21 September 2022)
The titled "APOE Alleles With Tau and Aβ Pathology In Patients With Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex in the Kii Peninsula" by Sasaki R et al. was published in the Jounal "Neurology (Impact Factor: 9.91)"
- Publication in the Journal "Rinsho Shinkeigaku (Clinical Neurology)" (4 December 2021)
The titled "Endemic paraplegia of Koza in Kii" in Honcho Koji Innen Shu published in 1689 is probably the earliest description of amyotrophic lateral sclerosis of Kii Peninsula: Presentation of the original and investigation of factuality" by Kuzuhara S et al. was published in the Jounal "Rinsho Shinkeigaku (Clinical Neurology) (Impact Factor: NA)"
- Publication in the Journal "Neurological Sciences" (4 December 2021)
The titled "An immigrant family with Kii amyotrophic lateral sclerosis/parkinsonism-dementia complex" by Kokubo Y et al. was published in the Jounal "Neurological Sciences (Impact Factor: 3.307)"
Schedule
Archive- Public Lecture in Minami-Ise Town
Minami-Ise Town Hall
October 13, 2013
- Neuropathological Workshop
Tokyo Metropolitan Institute of Gerontology
August 25, 2013
- Guam Research Project
Visiting to Guam at August 16-18, 2013