Yasumasa Kokubo MD, PhD
Mie University,
Graduate School of Regional Innovation Studies
Kii ALS/PDC Research Center
1577 Kurimamachiyacho, Tsu, Mie
514-8507, Japan
Phone & Fax:+81-059-231-5117


ALS/Parkinsonism-Dementia Complex of the Kii peninsula, Japan (Kii ALS/PDC)

The southern area in the Kii peninsula of Japan (Muro district) is one of the hyperendemic foci of amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia complex (PDC), together with Guam island. High accumulation of phosphorylated tau protein in neurons and glial cells in the central nervous system is the hallmark of ALS/PDC. Epidemiologically, marked decline in ALS incidence and concomitant increase in PDC incidence occurred in 1970s, suggesting changes of some unsolved environmental factors may have induced phenotypic changes of the disease. A research on genetic factors, environmental factors and their interaction is now going on.

Shigeki Kuzuhara, MD,PhD. Professor Emeritus of Neurology, Mie University


Publication in the Journal "Journal of Neuropathology & Experimental Neurology" (11 July 2020)

The titled "e PathomeBrain Transcriptome Analysis Links Deficiencies of Stress-Responsive Proteins to thchanism of Kii ALS/PDExpression of Mutant Ubiquitin and Proteostasis Impairment in Kii Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex Brains" by Bert M Verheijen et al. was published in the Jounal "Journal of Neuropathology & Experimental Neurology (Impact Factor: 3.714)"

Publication in the Journal "Antioxidants" (14 May 2020)

The titled "Brain Transcriptome Analysis Links Deficiencies of Stress-Responsive Proteins to the Pathomechanism of Kii ALS/PDC." by Morimoto S et al. was published in the Jounal "Antioxidants (Impact Factor: 4.520)"

30th International Symposium on ALS/MND (ALS/MND 2019)

30th International Symposium on ALS/MND (ALS/MND 2019)(Dec 4-6, 2019, Perth, Australia)

Yasumasa Kokubo presented the following theme「Poster Session: Abnormal accumulation of citrullinated proteins in ALS/PDC of the Kii peninsula of Japan

Shigeki Kuzuhara presented the following theme「Invited Oral Session: ALS-PDC of the Kii Peninsula,Japan: clinical and neuropathological features and epidemiology


Public Lecture in Minami-Ise Town

Minami-Ise Town Hall

October 13, 2013

Neuropathological Workshop

Tokyo Metropolitan Institute of Gerontology

August 25, 2013

Guam Research Project

Visiting to Guam at August 16-18, 2013