Yasumasa Kokubo MD, PhD
Mie University,
Graduate School of Regional Innovation Studies
Kii ALS/PDC Research Center
1577 Kurimamachiyacho, Tsu, Mie
514-8507, Japan
Phone & Fax:+81-059-231-5117


ALS/Parkinsonism-Dementia Complex of the Kii peninsula, Japan (Kii ALS/PDC)

The southern area in the Kii peninsula of Japan (Muro district) is one of the hyperendemic foci of amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia complex (PDC), together with Guam island. High accumulation of phosphorylated tau protein in neurons and glial cells in the central nervous system is the hallmark of ALS/PDC. Epidemiologically, marked decline in ALS incidence and concomitant increase in PDC incidence occurred in 1970s, suggesting changes of some unsolved environmental factors may have induced phenotypic changes of the disease. A research on genetic factors, environmental factors and their interaction is now going on.

Shigeki Kuzuhara, MD,PhD. Professor Emeritus of Neurology, Mie University


30th International Symposium on ALS/MND (ALS/MND 2019)

30th International Symposium on ALS/MND (ALS/MND 2019)(Dec 4-6, 2019, Perth, Australia)

Yasumasa Kokubo presented the following theme「Poster Session: Abnormal accumulation of citrullinated proteins in ALS/PDC of the Kii peninsula of Japan

Shigeki Kuzuhara presented the following theme「Invited Oral Session: ALS-PDC of the Kii Peninsula,Japan: clinical and neuropathological features and epidemiology

Publication in the Journal "Neurology"

The titled "Tau imaging detects distinctive distribution of tau pathology in ALS/PDC on the Kii Peninsula." by H.Shinotoh et al. was published in the Jounal "Neurology".

AOPMC2019 Plenary session

6th Asian and Oceanian Parkinson’s Disease and Movement Disorders Congress

April 12-14, 2019 • Hangzhou

Dr. Kokubo was invited as a speaker in Plenary session "Specific Movement Disorders in the Asian-Oceanian Region: Historical and Recent Developments".



Public Lecture in Minami-Ise Town

Minami-Ise Town Hall

October 13, 2013

Neuropathological Workshop

Tokyo Metropolitan Institute of Gerontology

August 25, 2013

Guam Research Project

Visiting to Guam at August 16-18, 2013